Services & Capabilities
Host Resistance Models & Antimicrobials

The goal of designing and performing animal models is to recapitulate human and animal disease. BRT uses these models to assess the functional capacity of the immune system. A variety of animal models are available to investigate host resistance to infection and non-communicable diseases in the context of toxicity or efficacy. Client-specific model development services are also available.

Models & Applications

  • Influenza virus in mice and rats
  • Antibody Dependent Enhancement (ADE) of viral replication in mice
  • Herpes virus in mice
  • Murine Cytomegalovirus (MCMV) (primary or latent viral reactivation studies)
  • Listeria monocytogenes in mice and rats
  • Streptococcus pneumoniae in mice and rats (pulmonary and systemic models)
  • Candida albicans in mice
  • Pseudomonas aeruginosa in mice and rats (pulmonary and systemic models)
  • Escherichia coli in mice and rats (pulmonary, systemic, and peritonitis models)
  • Staphylococcus aureus in mice and rats (pulmonary, systemic, and wound infection models)
  • Neisseria meningitidis
  • Syngeneic tumor model
    • B16F10 melanoma cell model
    • PYB6 sarcoma cell model

Assays & Platforms

  • Plaque Assay
  • Infectious Center Assay
  • Hemagglutination yield reduction
  • Colony Forming Cell Assay
  • Bacterial culture and enumeration
  • Fungal culture and enumeration
  • Viral quantification
  • Antimicrobial testing
  • Colony imaging
  • Immune function evaluations
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