Services & Capabilities
Host Resistance Models & Antimicrobials
The goal of designing and performing animal models is to recapitulate human and animal disease. BRT uses these models to assess the functional capacity of the immune system. A variety of animal models are available to investigate host resistance to infection and non-communicable diseases in the context of toxicity or efficacy. Client-specific model development services are also available.
Models & Applications
- Influenza virus in mice and rats
- Antibody Dependent Enhancement (ADE) of viral replication in mice
- Herpes virus in mice
- Murine Cytomegalovirus (MCMV) (primary or latent viral reactivation studies)
- Listeria monocytogenes in mice and rats
- Streptococcus pneumoniae in mice and rats (pulmonary and systemic models)
- Candida albicans in mice
- Pseudomonas aeruginosa in mice and rats (pulmonary and systemic models)
- Escherichia coli in mice and rats (pulmonary, systemic, and peritonitis models)
- Staphylococcus aureus in mice and rats (pulmonary, systemic, and wound infection models)
- Neisseria meningitidis
- Syngeneic tumor model
- B16F10 melanoma cell model
- PYB6 sarcoma cell model
Assays & Platforms
- Plaque Assay
- Infectious Center Assay
- Hemagglutination yield reduction
- Colony Forming Cell Assay
- Bacterial culture and enumeration
- Fungal culture and enumeration
- Viral quantification
- Antimicrobial testing
- Colony imaging
- Immune function evaluations
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