Services & Capabilities

Host Resistance Models

The goal of designing and performing host resistance models is to recapitulate the response to human and animal disease. BRT uses host resistance and disease models to evaluate efficacy and assess the functional capacity of the immune system. Our host resistance models are essential for evaluating the potential immunological impact of candidate therapeutics or chemicals of interest. 

We have a range of models and infectious agents available (bacterial, viral, or fungal) to investigate host resistance to infection and non-communicable diseases in the context of toxicity or efficacy. 

Client-specific model development services are also available.

Models & Applications
  • Influenza virus in mice and rats
  • Antibody Dependent Enhancement (ADE) of viral replication in mice
  • Herpes virus in mice
  • Murine Cytomegalovirus (MCMV) (primary or latent viral reactivation studies)
  • Listeria monocytogenes in mice and rats
  • Streptococcus pneumoniae in mice and rats (pulmonary and systemic models)
  • Candida albicans in mice
  • Pseudomonas aeruginosa in mice and rats (pulmonary and systemic models)
  • Escherichia coli in mice and rats (pulmonary, systemic, and peritonitis models)
  • Staphylococcus aureus in mice and rats (pulmonary, systemic, and wound infection models)
  • Neisseria meningitis
  • Syngeneic tumor model
    • B16F10 melanoma cell model
    • PYB6 sarcoma cell model
Assays & Platforms
  • Plaque Assay
  • Infectious Center Assay
  • Hemagglutination yield reduction
  • Colony Forming Cell Assay
  • Bacterial culture and enumeration
  • Fungal culture and enumeration
  • Viral quantification
  • Antimicrobial testing
  • Colony imaging
  • Immune function evaluations

Starting a study?