Hypersensitivity and adverse immune reactions are important considerations in human and animal health risk assessment. BRT offers testing strategies both In Vitro and In Vivo to understand the risks, mechanisms, and adverse outcome pathways.
Models & Applications
Infusion studies
Local Lymph Node Assay (LLNA)
Irritancy testing
In vivo histamine release
In vivo evaluation of Type I and Type III hypersensitivity
Clinical characterization
Assessment of immediate hypersensitivity – histamine, leukotrienes
Assessment of immune-complexed mediated hypersensitivity
