Services & Capabilities

Hypersensitivity Testing

Hypersensitivity and adverse immune reactions are important considerations in human and animal health risk assessment.

BRT Labs offers a range of testing services to evaluate the hypersensitivity potential associated with test compounds in early-stage drug development. Our hypersensitivity tests provide valuable information for assessing product safety by using state-of-the-art technology and assays that measure the product’s effects on the relevant immune system pathways. We offer testing strategies both in vitro and in vivo to understand the risks, mechanisms, and potential adverse outcomes.


Models & Applications
  • Infusion studies
  • Local Lymph Node Assay (LLNA)
  • Irritancy testing
  • In vivo histamine release
  • In vivo evaluation of Type I and Type III hypersensitivity
    • Clinical characterization
    • Assessment of immediate hypersensitivity – histamine, leukotrienes
  • Assessment of immune-complexed mediated hypersensitivity
Assays & Platforms
  • HPLC
  • ELISA (absorbance, fluorescence, luminescence, electrochemiluminescence)
  • Multiplex technologies
    • Meso Scale Discovery (MSD)
  • Flow cytometry
  • Mast Cell/Basophil Activation Assay
  • In vitro Immediate Hypersensitivity/Histamine Release Assay
  • Complement activation using in vivo and in vitro test systems
  • In vitro testing for skin sensitization (DPRA, KeratinoSens, LuSens, hCLAT, GARD)
  • In vitro testing for respiratory sensitizers (GARD)
  • Cytokine Release Syndrome

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Our In Vitro Test Offerings

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