In Vivo Services & Capabilities

In Vivo Rodent Models

Using in vivo rodent models (mouse and rat), BRT evaluates immune function, host resistance, and therapeutic efficacy across a wide range of disease areas—from infectious disease and host resistance models to immunopharmacology and efficacy studies.

Our AAALAC-accredited vivarium and experienced team support both standard and complex studies, integrating in vivo and ex vivo assessments to provide a complete evaluation of immune function and therapeutic efficacy.

Explore our in vivo rodent models and capabilities below.

Host resistance & Infectious Disease

  • Bacterial, viral, and fungal infection models
  • Influenza (A & B), herpesvirus (HSV-1), CMV, and more
  • Pulmonary, systemic, and wound infection models
  • Antimicrobial efficacy testing
  • Tumor models (melanoma, sarcoma, syngeneic)

Immunotoxicology

  • T-Dependent Antibody Response (TDAR)
  • Developmental and aging models
  • Immune function assays (NK cell activity, CTL, proliferation)
  • Macrophage and neutrophil function
  • Host resistance in the context of toxicity
  • Metabolic and exposure-based immunotoxicity studies

Immunopharmacology & Efficacy

  • PK/TK and metabolic studies
  • Dose-response and mechanism of action
  • Infusion studies
  • Telemetry, real-time temperature, and activity monitoring
  • Non-communicable disease models (e.g., dry eye)

Hypersensitivity

  • Local Lymph Node Assay (LLNA)
  • In vivo histamine release
  • Type I & Type III hypersensitivity models
  • Irritation and sensitization assessments
  • Clinical immune response characterization

Humanized & Immunocompromised

  • Human-specific target evaluation
  • Immune system modeling using human cells and tissues
  • Immunotherapy safety and efficacy
  • NSG, SCID, nude, and CD34+ models
Integrated In Vivo & Ex Vivo Capabilities
  • Cytokine and biomarker analysis (ELISA, ELISpot)
  • Flow cytometry and immunophenotyping
  • T-cell, B-cell, and NK cell functional assays
  • Macrophage and neutrophil function (phagocytosis, respiratory burst)
  • Microbial quantification and culture
  • Complement activation and histamine release
  • Integration with in vitro assays for comprehensive immune assessment
Study Design, Dosing, & Exposure Capabilities
  • Oral (gavage), IV, IP, IM, subcutaneous, intranasal, dermal, pharyngeal aspiration, and infusion routes
  • Dosed feed and drinking water studies
  • Flexible study durations (acute, 28-day, 90-day, and custom designs)
  • Real-time temperature and activity monitoring for humane endpoints
  • Custom protocol development aligned with study objectives

Starting a study?

request a quote
BRT Logo_Primary
Facebook Linkedin Instagram

Main Office

Service Areas

Site Links

Join Our Mailing List

Ⓒ 2025 - All Rights Are Reserved